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Accurate impressions are important elements in both the fabrication and maintenance phases of complete denture therapy. For patients possessing nonrestorable, periodontally hopeless residual dentitions, immediate denture therapy is often the treatment of choice. An impression procedure capable of accurately registering functional vestibular anatomy facilitates successful therapy. For complete dentures currently in function, periodic assessment and correction of fit extends long-term prosthesis performance. To maintain optimal tissue-base relationships, use of specialized impressions, and subsequent laboratory reline procedures is often indicated. For both of these impression procedures (ie, immediate denture impressions and denture reline impressions), vinyl polysiloxane (VPS) impression material offers distinct advantages. Part 2 of this article series reports on the use of VPS for immediate denture and reline impression procedures.