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The goal of a dental infection control program is to provide a safe working environment that will reduce the risk of health care–associated infections among patients and occupational exposures among staff members. Minimizing the potential for percutaneous sharps injuries is a primary focus for a comprehensive infection control program. This article will review the advantages of using instrument cassettes, as well as provide an overview of engineering and work practice controls and instrument processing, to emphasize how appropriate use of instrument cassettes can improve office safety and infection control.